The clinical and epidemiological importance of chronic B hepatitis is currently unquestionable as a cause of end-stage liver disease and hepatocellular carcinoma. Recently, predictors of treatment response of this disease have been studied, both before and during the course of medication. Therapy stopping rules have been proposed, which may be useful in patients presenting poor treatment tolerance. This review discusses the treatment response predictors usefulness, with emphasis on ALT, quantitative HBsAg and HBeAg, quantitative HBV-DNA and HBV genotype.
Journal Information
Vol. 14. Issue 5.
Pages 519-525 (September - October 2010)
Vol. 14. Issue 5.
Pages 519-525 (September - October 2010)
Review article
Open Access
Response predictors to treatment with pegylated interferon in chronic hepatitis B
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Paulo Roberto Abrão Ferreira1,
, Simone de Barros Tenore2
Corresponding author
paulo.abrao.ferreira@gmail.com
Correspondence to: Rua Ouvidor Peleja, 235, ap 101 Vila Mariana - São Paulo – SP – Brazil CEP: 04128000.
Correspondence to: Rua Ouvidor Peleja, 235, ap 101 Vila Mariana - São Paulo – SP – Brazil CEP: 04128000.
1 Physician of the HIV and Viral Hepatitis Outpatient Clinic of the Discipline of Infectious Diseases of UNIFESP; Member of the Viral Hepatitis Group of CRT STD-Aids in São Paulo - Brazil
2 Master's Degree in Infectology by UNIFESP; Assisting Physician at HIV and Hepatitis Outpatient Clinic at UNIFESP; Physician of the Viral Hepatitis Group at CRT DST-Aids in São Paulo - Brazil
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Abstract
Keywords:
hepatitis B
HBsAg
HBeAg
HBV-DNA
pegylated interferon
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