Article information
Abstract
Staphylococcus lugdunensis is a rare cause of severe infections and clinical manifestations are similar to those related to S. aureus infection. We describe a hospital-acquired bacteremia due to methicillin-resistant Staphylococcus lugdunensis, misidentified as methicillin-resistant S. aureus. The oxacillin MIC was 16 μg/mL and the mecA gene and SCCmec type V were determined by PCR. Although treatment had been appropriated, the patient died after rapid progressive respiratory failure and another nosocomial sepsis. It is important not only to identify S. lugdunensis in view of its clinical course, but also to determine its susceptibility to oxacillin by detecting the mecA gene or its product.
Keywords:
Staphylococcus
methicillin resistance
bacteremia
Full text is only aviable in PDF
References
[1.]
L.A. Mermel, M. Allon, E. Bouza, et al.
Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.
Clin Infect Dis, 49 (2009), pp. 1-45
[2.]
E.M. Pereira, F.L. Oliveira, R.P. Schuenck, G.O. Zoletti, K.R. dos Santos.
Detection of Staphylococcus lugdunensis by a new species-specific PCR based on the fbl gene.
FEMS Immunol Med Microbiol, 58 (2010), pp. 295-329
[3.]
T.E. Herchline, L.W. Ayers.
Occurrence of Staphylococcus lugdunensis in consecutive clinical cultures and relationship of isolation to infection.
J Clin Microbiol, 29 (1991), pp. 419-421
[4.]
Y. Kondo, T. Ito, X.X. Ma, et al.
Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions.
Antimicrob Agents Chemother, 51 (2007), pp. 264-274
[5.]
E. Kawaguchi, W. Minamide, H. Mori, H. Igmi.
The taxonomic distribution, characteristic and susceptibility against antimicrobial agents of methicillin-resistant staphylococci isolated from blood.
Kansenshogaku Zasshi, 70 (1996), pp. 1147-1153
[6.]
W.S. Tee, S.Y. Soh, R. Lin, L. Loo.
Staphylococcus lugdunensis carrying the mecA gene causes catheter-associated bloodstream infection in premature neonate.
J Clin Microbiol, 41 (2003), pp. 519-520
[7.]
T.Y. Tan, S.Y. Ng, J. He.
Microbiological characteristics, presumptive identification, and antibiotic susceptibilities of Staphylococcus lugdunensis.
J Clin Microbiol, 46 (2008), pp. 2393-2395
[8.]
J. Freney, Y. Brun, M. Bes, et al.
Staphylococcus lugdunensis Staphylococcus schleiferi sp. nov two species from human clinical specimens.
Int J Syst Bacteriol, 38 (1988), pp. 168-172
[9.]
K.L. Frank, J.L. Del Pozo, R. Patel.
From clinical microbiology to infection pathogenesis: how daring to be different works for Staphylococcus lugdunensis.
Clin Microbiol Rev, 21 (2008), pp. 111-133
[10.]
J.R. Ebright, N. Penugonda, W. Brown.
Clinical experience with Staphylococcus lugdunensis bacteremia: a retrospective analysis.
Diagn Microbiol Infec Dis, 48 (2004), pp. 17-21
[11.]
S. Böcher, B. Tønning, R.L. Skov, J. Prag.
Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community.
J Clin Microbiol, 47 (2009), pp. 946-950
Copyright © 2011. Elsevier Editora Ltda.. All rights reserved
