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Vol. 15. Issue 2.
Pages 170-173 (March - April 2011)
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Vol. 15. Issue 2.
Pages 170-173 (March - April 2011)
Brief Comunication
Open Access
Clinical aspects of influenza A (H1N1) in HIV-infected individuals in São Paulo during the pandemic of 2009
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Rosana Del Bianco1, Maria Silvia Biagioni Santos2,
Corresponding author
msbiagioni@gmail.com

Correspondence to: CRT DST AIDS, Rua Santa Cruz 81, Vila Mariana, São Paulo, SP, Brazil. Phone: +55-11-50879887, Fax: +55-11-50879886.
, Maria Clara Gianna Garcia Ribeiro3, Ana Teresa Rodriguez Viso4, Valquíria Carvalho5
1 Master's Degree in Infectology; Director of Inpatient Service, CRT DST AIDS-SES SP
2 Infectologist; Physician of Inpatient Service, CRT DST AIDS-SES SP
3 Sanitarist; Technical Director, CRT DST AIDS-SES SP
4 Infectology; Director of Ambulatory Service, CRT DST AIDS-SES SP
5 Master's Degree in Infectology; Physician of Inpatient Service, CRT DST AIDS-SES SP
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Article information
Abstract
Objective

To describe the clinical aspects of H1N1 among HIV coinfected patients seen at a reference center for AIDS treatment in São Paulo, Brazil.

Design

Observational and prospective cohort study.

Methods

Descriptive study of clinical and laboratory investigation of HIV-infected patients with confirmed diagnosis of influenza A (H1N1) in 2009. We analyzed patients monitored in CRT/DST/AIDS, a specialized service for people living with HIV, located in São Paulo, Brazil.

Results

108 individuals presented with symptoms of H1N1 infection at the CRT DST/AIDS in 2009. Eighteen patients (16.7%) had confirmation of the diagnosis of influenza A. Among the confirmed cases, ten (55.6%) were hospitalized and eight (44.4%) were outpatients. Dyspnea was present in nine patients (50%), hemoptysis in three (16%). Six patients (60%) required therapy with supplemental oxygen. All patients had good clinical outcomes and none died.

Conclusions

In our hospital, the symptoms that led patients to seek medical care were similar to the common flu. Hospital admission and the early introduction of antibiotics associated with oseltamivir may have been the cause of the favorable outcome of our cases.

Keywords:
influenza A virus, H1N1 subtype
HIV
acquired immunodeficiency syndrome
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References
[1.]
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza.
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection.
N Engl J Med, 362 (2010), pp. 17081719
[2.]
Centro de Vigilância Epidemiológica “Prof. Alexandre Vranjac”.
Coordenadoria de Controle de Doenças. Secretaria de Estado da Saúde. São Paulo, SP, Brasil Informe epidemiológico influenza pandêmica H1N1 2009 – Abril, 2010.
Bepa Abril, 7 (2010),
[3.]
G.D. Freitas, T.R.M.P. Carvalhanas, B.L. Liphaus, et al.
Influenza A/H1N1: cenário atual e novos desafios.
BEPA, Bol. epidemiol. paul., 6 (2009), pp. 2430
[4.]
S. Jain, L. Kamimoto, A.M. Bramley, et al.
Hospitalized Patients with 2009 H1N1 Influenza in the United States, April June 2009.
N Engl J Med, 361 (2009), pp. 193544
[5.]
Clinical management of human infection with pandemic (H1N1) 2009: revised guidance. Geneva: World Health Organization, November 2009.
[6.]
Updated Interim Recommendations — HIV Infected Adults and Adolescents: Considerations for Clinicians Regarding 2009 H1N1 Influenza. Atlanta: Centers for Disease Control and Prevention, October, 21, 2009. www.cdc.gov/h1n1flu/guidance_hiv.htm.
[7.]
C. Del Rio.
New CDC Interim Guidance on HIV and H1N1.
Journal Watch HIV/AIDS Clinical Care, (2009),
[8.]
G. Aviram, A. Bar-Shai, J. Sosna, et al.
H1N1 influenza: initial chest radiographic findings in helping predict patient outcome.
Radiology, 255 (2010), pp. 2529
[9.]
Morbidity and Mortality Weekly Report www.cdc.gov/mmwr. Bacterial Coinfections in Lung Tissue Specimens from Fatal Cases of 2009. Pandemic Influenza A (H1N1) — United States, May – August 2009. 2009; 58 (Early Release):14.
[10.]
G.R. Teran, D. de la Rosa Zamboni, Y. Vázquez Pérez, et al.
Clinical Features of Subjects Infected with HIV and H1N1 Influenza Vírus. Inst Natl de Enfermedades Respiratorias, Mexico City, Mexico.
Program and abstracts: 17a Conferences on Retroviruses and Opportunistic Infections, CROI, (2010),
[11.]
Zarychanski R, Stuart TL, Kumar A, et al. Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. Early release, published at www.cmaj.ca on January 21, 2010. Subject to revision.
[12.]
A. McGeer, K.A. Green, A. Plevneshi, et al.
Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario.
Canada. Clin Infect Dis, 45 (2007), pp. 156875
[13.]
N. Lee, C.S. Cockram, P.K. Chan, et al.
Antiviral treatment for patients hospitalized with severe influenza infection may affect clinical outcomes.
Clin Infect Dis, 46 (2008), pp. 13234
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