Dengue virus is the most important mosquito-borne viral disease in the world. Co-circulation of the four types of dengue viruses and expansion of dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the disease. Herein we report a case of a 25-year-old white woman with dengue fever and numerous associated autoimmune features. Our patient had proteinuria, an extensive right pleural effusion, a thin pericardial effusion and ascites. She had a low C3 level and positive antinuclear antibody; cryoglobulins were also positive. The numerous autoimmune features of this patient were a diagnostic challenge, since she was a young woman and could be easily mistaken for a rheumatologic patient in a newly open disease. Dengue infection probably was a triggering event causing an abnormal immune response. Therefore, dengue should be suspected in patients with hematological disorders and autoimmune features in endemic regions or those who have travelled to those regions.
Journal Information
Vol. 16. Issue 1.
Pages 92-95 (January - February 2012)
Vol. 16. Issue 1.
Pages 92-95 (January - February 2012)
Open Access
Autoimmune features caused by dengue fever: a case report
Visits
3779
Denis Leonardo Fontes Jardim
, Daniela Miti Lemos Tsukumo, Rodrigo N. Angerami, Marco Antonio de Carvalho Filho, Mário José Abdalla Saad
Corresponding author
jardimde@gmail.com
Corresponding author at: Rua Tessália Vieira de Camargo, 126, Cidade Universitária “Zeferino Vaz”, 13083-887, Campinas, SP, Brazil.
Corresponding author at: Rua Tessália Vieira de Camargo, 126, Cidade Universitária “Zeferino Vaz”, 13083-887, Campinas, SP, Brazil.
Department of Internal Medicine, Universidade Estadual de Campinas, Campinas, SP, Brazil
This item has received
Article information
Abstract
Keywords:
Dengue
Autoimmunity
Hematologic diseases
Full text is only aviable in PDF
References
[2.]
S.B. Halstead.
Dengue.
Lancet, 370 (2007), pp. 1644-1652
[3.]
S. Green, A. Rothman.
Immunopathological mechanisms in dengue and dengue hemorrhagic fever.
Curr Opin Infect Dis, 19 (2006), pp. 429-436
[4.]
D.W. Vaughn, S. Green, S. Kalayanarooj, et al.
Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.
J Infect Dis, 181 (2000), pp. 2-9
[5.]
C.F. Lin, H.Y. Lei, A.L. Shiau, et al.
Antibodies from dengue patient sera cross-react with endothelial cells and induce damage.
J Med Virol, 69 (2003), pp. 82-90
[6.]
C.F. Lin, S.W. Wan, H.J. Cheng, et al.
Autoimmune pathogenesis in dengue virus infection.
Viral Immunol, 19 (2006), pp. 127-132
[7.]
T. Srichaikul, S. Nimmannitya.
Haematology in dengue and dengue haemorrhagic fever.
Baillieres Best Pract Res Clin Haematol, 13 (2000), pp. 261-276
[8.]
B.A. Wills, E.E. Oragui, A.C. Stephens, et al.
Coagulation abnormalities in dengue hemorrhagic fever: serial investigations in 167 Vietnamese children with dengue shock syndrome.
Clin Infect Dis, 35 (2002), pp. 277-285
[9.]
A. Mathew, A.L. Rothman.
Understanding the contribution of cellular immunity to dengue disease pathogenesis.
Immunol Rev, 225 (2008), pp. 300-313
Copyright © 2012. Elsevier Editora Ltda.. All rights reserved