Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin with a wide range of clinical manifestations. Commonly, the clinical features of CBCL are plaques, nodules, or ulcerative lesions. Skin is one of the common sites for extra-nodal lymphomas in patients with AIDS and B cell type is less common than T cell type. Only recently, the existence of B cell lymphomas presenting clinically in the skin without evidence of extra-cutaneous involvement has been accepted as primary CBCL. Here, we are presenting 5 patients with cutaneous involvement in the setting of HIV/AIDS disease. Two of them were primary cutaneous non-Hodgkin lymphomas. All were CBCL; 3 were immunoblastic, 1 was plasmablastic, and the other was a Burkitt lymphoma. We analyzed the epidemiological, clinical, virological, and immunological characteristics of this group of patients.
Journal Information
Vol. 14. Issue 1.
Pages 81-85 (January - February 2010)
Vol. 14. Issue 1.
Pages 81-85 (January - February 2010)
Case Report
Open Access
Non Hodgkin's lymphoma with cutaneous involvement in AIDS patients. Report of five cases and review of the literature
Visits
2721
Marcelo Corti1,
, Luis De Carolis1, Rubén Solari1, María F. Villafañe1, Ricardo Schtirbu2, Daniel Lewi3, Marina Narbaitz4
Corresponding author
marcelocorti@fibertel.com.ar
Correspondence to: Division of HIV/AIDS disease Puán 381, 2° piso, C1406CQG Buenos Aires, Argentina.
Correspondence to: Division of HIV/AIDS disease Puán 381, 2° piso, C1406CQG Buenos Aires, Argentina.
1 HIV/AIDS Division, Infectious Diseases F. J. Muñiz Hospital, Argentina
2 Histopathology Laboratory, Infectious Diseases F. J. Muñiz Hospital, Argentina
3 Oncology Section, General Acute Hospital J. A. Fernández, Argentina
4 Histopathology Laboratory, National Academy of Medicine; Buenos Aires, Argentina
This item has received
Article information
Abstract
Keywords:
AIDS
HIV
cutaneous lymphoma
Full text is only aviable in PDF
References
[1.]
D.D. Weisenburger.
Epidemiology of non-Hodgkin's lymphoma. Recent findings regarding an emerging epidemic.
Ann Oncol, (1994), pp. S19-S24
[2.]
M. Corti, M.F. Villafañe, L. Souto, et al.
Burkitt's lymphoma of the duodenum in a patient with AIDS.
Rev Soc Bras Med Trop, 40 (2007), pp. 338-340
[3.]
M.K. Gandhi, R. Khanna.
Viruses and lymphoma.
Pathology, 37 (2005), pp. 420-423
[4.]
M. Corti, R. Solari, D. Cangelosi, et al.
Oral cavity lymphoma as a secondary AIDS-defining neoplasm in a patient on HAART with immune reconstitution.
Rev Soc Bras Med Trop, 40 (2007), pp. 582-584
[5.]
R. Willemze, C.J. Meijer.
EORTC classification for primary cutaneous lymphomas: the best guide to good clinical management. European Organization for Research and Treatment of Cancer.
Am J Dermopathol, 21 (1999), pp. 265-273
[6.]
G. Goteri, R. Ranaldi, O. Simonetti, et al.
Clinicopathological features of primary cutaneous B-cell lymphomas from an academic regional hospital in central Italy: No evidence of Borrelia burgdorferi association.
Leukemia & Lymphoma, 48 (2007), pp. 2184-2188
[7.]
C. Diamond, T.H. Taylor, T.H. Im, Anton-Culver.
Presentation and outcomes of systemic non-Hodgkin's lymphomas: A comparisson between patients with acquired immunodeficiency syndrome (AIDS) treated with highly active antiretroviral therapy and patients without AIDS.
Leukemia & Lymphoma, 47 (2006), pp. 1822-1829
[8.]
R. Dummer, K. Asagoe, A. Cozzio, et al.
Recent advances in cutaneous lymphomas.
J Dermatol Sci, 48 (2007), pp. 157-167
[9.]
R. Willemze, E.S. Jaffe, G. Burg, et al.
WHO-EORTC classification for cutaneous lymphomas.
Blood, 105 (2005), pp. 3768-3785
[10.]
M. Beylot-Barry, B. Vergier, B. Masquelier, et al.
The spectrum of cutaneous lymphomas in HIV infection: A study of 21 cases.
Am J Surg Pathol, 23 (1999), pp. 1208-1216
[11.]
S. Camilleri-Broet, F. Davi, J. Feuillard, et al.
High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency-related primary brain lymphomas.
Blood, 86 (1995), pp. 432-435
[12.]
C. Allen, J. Kalmar, S. Suster, R. Baiocchi, G. Nuovo.
Oral plasmablastic lymphomas in AIDS patients are associated with Human Herpesvirus 8.
Am J Surg Pathol, 28 (2004), pp. 41-44
[13.]
F. Grange, M.W. Bekkenk, J. Weschsler, et al.
Prognostic factors in primary cutaneous large B-cell lymphomas: A European multicenter study.
J Clin Oncol, 19 (2001), pp. 3602-3610
Copyright © 2010. Elsevier Editora Ltda.. All rights reserved