The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a significant shift in the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and early management of suspected cases.
Journal Information
Vol. 14. Issue 3.
Pages 242-251 (May - June 2010)
Vol. 14. Issue 3.
Pages 242-251 (May - June 2010)
Original article
Open Access
Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil
Visits
2806
David Eduardo Barroso1,2,3,
, D.M. Carvalho2, S.T. Casagrande4, M.C. Rebelo1, V. Soares1, V. Zahner3, C.A. Solari5, S.A. Nogueira1,2
Corresponding author
barroso@ioc.fiocruz.br
Correspondence to: Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz Av. Brasil, 4365 Rio de Janeiro – RJ – Brazil CEP: 21040-900.
Correspondence to: Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz Av. Brasil, 4365 Rio de Janeiro – RJ – Brazil CEP: 21040-900.
1 Instituto Estadual de Infectologia São Sebastião, Rio de Janeiro, RJ, Brazil
2 Department of Preventive Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
3 Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
4 Bacteriology Section, Instituto Adolfo Lutz, São Paulo, SP, Brazil
5 Department of Bacteriology, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Article information
Abstract
Keywords:
Neisseria meningitidis
meningococcal disease
epidemic
meningitis
sepsis
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