Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon

Ramos Júnior, Wilson M.; Sardinha, José F.J.; Costa, Mônica R.F.; Santana, Marli S.; Alecrim, Maria G.C.; Lacerda, Marcus V.G.

doi:10.1016/S1413-8670(10)70084-2

The Brazilian Journal of Infectious Diseases

ISSN: 1413-8670

The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents.
The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor. Since its inception it has garnered a growing share of the publishing market.

Indexed in:

CABI Publishing; Chemical Abstracts (CAS); China Education Publications Import and Export Corporation (CEPIEC); EBSCO Database (Premium Research); Elsevier Science - Bibliographic Databases Division; Embase/Excerpta Medica; Gale Cengage Learning; Index Copernicus International; ISI (Web of Science) - Science Citation Index Expanded (SCISEARCH); Journal Citation Reports (Science Edition); Kessler-Hancok Information Service; Latin America and Caribean Literature of Health Science (LILACS); LATINDEX; Medline/ Index Medicus/Pubmed; Qualis International (CAPES): B3 (International Quality); Redalyc (Network of Scientific Journals of Latin America, Caribbean, Spain and Portugal) SCIELO; SCIRUS (Elsevier); SCOPUS Index; Sociedad Iberoamericana de Información Cientifica (SIIC); Subis Database (SUBIS Bulletin); Swets Blackwell; Teldan Database Production; The US Library of Congress Office; Ulrich¿s Periodicals Directory.

This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.

Keywords:

malaria

Plasmodium vivax

treatment

primaquine

hemolysis

Full text is only aviable in PDF

References

[1.]

Brazilian Ministry of Health. Epidemiology of Malaria in Brazil, 2007. Available at: http://portal.saude.gov.br/portal/arquivos/pdf/folder_malaria_2008_final.pdf. Accessed 17 November 2009.

[2.]

W.A. Krotoski.

The hypnozoite and malarial relapse.

Prog Clin Parasitol, 1 (1989), pp. 1-19

Medline

[3.]

Brazilian Ministry of Health. Brazilian Antimalarial Therapy Guideline. Available at: http://portal.saude.gov.br/portal/arquivos/pdf/manu_terapeutica_malaria.pdf. Accessed 19 March 2009.

[4.]

S. Krudsood, N. Tangpukdee, P. Wilairatana, et al.

High-dose primaquine regimens against relapse of Plasmodium vivax malaria.

Am J Trop Med Hyg, 78 (2008), pp. 736-740

Medline

[5.]

J.K. Baird, S.L. Hoffman.

Primaquine therapy for malaria.

Clin Infect Dis, 39 (2004), pp. 1336-1345

http://dx.doi.org/10.1086/424663 | Medline

[6.]

World Health Organization.

Glucose-6-phosphate dehydrogenase deficiency.

Bull World Health Organ, 67 (1989), pp. 601-611

Medline

[7.]

E. Beutler, S. Duparc.

Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development.

Am J Trop Med Hyg, 77 (2007), pp. 779-789

Medline

[8.]

M.S. Santana, M.A. Rocha, A.R. Arcanjo, et al.

Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine.

Rev Soc Bras Med Trop, 40 (2007), pp. 533-536

Medline

[9.]

G.J. Brewer, A.R. Tarlov, A.S. Alving.

The methemoglobin reduction test for primaquine-type sensitivity of erythrocytes. A simplified procedure for detecting a specific hypersusceptibility to drug hemolysis.

JAMA, 180 (1962), pp. 386-388

Medline

[10.]

M.C. Silva, E.B. Santos, E.G. Costal, et al.

Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6 -phosphate dehydrogenase deficiency treated with primaquine at 0.50 mg/kg/day.

Rev Soc Bras Med Trop, 37 (2004), pp. 215-217

Medline

[11.]

M.E. Carr Jr., M.N. Fandre, F.O. Oduwa.

Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria.

Mil Med, 170 (2005), pp. 273-276

Medline

[12.]

V. Sakhuja, K. Sud.

Acute renal failure in the tropics.

Saudi J Kidney Dis Transplant, 4 (1999), pp. 247-260

[13.]

M.S. Santana, M.V.G. Lacerda, M.G.V. Barbosa, et al.

Glucose-6- phosphate dehydrogenase deficiency in an endemic area for malaria in Manaus: a cross-sectional survey in the Brazilian Amazon.

PLoS ONE, 4 (2009), pp. e5259

http://dx.doi.org/10.1371/journal.pone.0005259 | Medline