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Vol. 22. Num. 3.May - June 2018
Pages 159-256
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Vol. 22. Num. 3.May - June 2018
Pages 159-256
Letter to the Editor
DOI: 10.1016/j.bjid.2018.05.006
Open Access
Immediate start of antiretroviral, why not?
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Elaine Monteiro Matsudaa, Luana Portes Ozório Coelhob, Cintia Mayumi Ahagonc, Ivana Barros Camposc, Luís Fernando de Macedo Brígidob,
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lubrigido@gmail.com

Corresponding author.
a Programa IST/AIDS de Santo André, Santo André, SP, Brazil
b Instituto Adolfo Lutz, Centro de Virologia, NDSS, São Paulo, SP, Brazil
c Instituto Adolfo Lutz, Regional Santo André, Santo André, SP, Brazil
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Brazil has adopted universal antiretroviral treatment (ART) in 2013 as part of the strategy for the prevention of new infections.1 In the following year UNAIDS launched the 90-90-90 goal aiming to end the AIDS epidemic by 2030.2 In spite of evidence that prompt initiation of ART may benefit patients and the community,3,4,5 access to ART in Brazil still faces different obstacles. This may be especially true for patients at acute phase of infections, a period of heightened transmission4,5 and when treatment delay may impact future cure strategies.6 Local difficulties to implement early treatment include referral services with limited first-time appointment or even closed for new cases, a scenario that results in long waiting periods. Moreover, some physicians at primary health units and even at specialized services opt to initiate ART only after lab exams results have turned out to rule out comorbidities, rather then initiating ART regimen and modifying it later as needed. Indeed, the same drugs are being used for post-exposure prophylaxis (PEP), prescribed without this information. Staging disease with CD4 T cell counts also does not justify waiting any longer,1,7 except for patients with some clinical AIDS conditions associated to the risk of severe immune reconstitution syndrome, as when active tuberculosis or cryptococcosis are suspected.7 All patients may benefit from treatment, in particular patients who report recent signs and symptoms compatible with Acute Retroviral Syndrome.4,5 Even when elite controllers are considered (about 1% of the patients), ART may be subsequently suspended if necessary. Faced with the delays of our HIV treatment scenario, we report a curious and insightful way used by a patient to overcome the difficulties described above. One month after a negative HIV test with oral fluids purchased abroad, a 40-year-old Brazilian man who have sex with men presented with sore throat, cervical adenomegaly and asthenia. After medical consultation, he tested positive at chemiluminescence and rapid immunoblot, with a p31 negative band. With results obtained through the internet and aware through friends and other resources of the potential benefits of immediate treatment, but unable to have a same day consultation, he found out the same antiretroviral regimen is used for both initial treatment and PEP. He then sought an emergency room service, reporting recent risk exposure, but omitting the positive HIV test. No HIV testing was performed at this occasion and he started PEP on the same day, possibly still at Fiebig stage IV. As consultation after one month was not possible, he used this alternative once more. At the first regular visit he disclosed the situation and was prescribed therapy accordingly. This illustrates a creative way a patient used to circumvent administrative obstacles of some services. Simple changes based in scientific knowledge and common sense must be sought to improve current treatment access, particularly to a motivated patient, that is clearly recommended but still with limited application, albeit the potential benefit to patients and for controlling the HIV/AIDS epidemic.

Source of Funding: FAPESP grants (Award Numbers: PPSUS 2016/14813-1 and 2017/03022-6).

Conflicts of interest

The author declares no conflicts of interest.

References
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Ministério da Saúde
Secretaria de Vigilância em Saúde Departamento de Vigilância, Prevenção e Controle das Infecções Sexualmente Transmissíveis, do HIV/Aids e das Hepatites Virais. Protocolo clínico e diretrizes terapêuticas para manejo da infecção pelo hiv em adultos. Brasília
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The Lancet
The global HIV/AIDS epidemic-progress and challenges
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RM Ribeiro,L Qin,LL Chavez,D Li,SG Self,AS Perelson
Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection
J Virol, 84 (2010), pp. 6096-7102 http://dx.doi.org/10.1128/JVI.00127-10
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Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok
J Int AIDS Soc, 28 (2017), pp. 21708 http://dx.doi.org/10.7448/IAS.20.1.21708
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SE Rutstein,J Ananworanich,S Fidler,C Johnson,EJ Sanders,O Sued,A Saez-Cirion,CD Pilcher,C Fraser,MS Cohen,M Vitoria,M Doherty,JD Tucker
Clinical and public health implications of acute and early HIV detection and treatment: a scoping review
J Int AIDS Soc, 28 (2017), pp. 21579 http://dx.doi.org/10.7448/IAS.20.1.21579
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J. Ananworanich
What will it take to cure HIV?
Top Antivir Med, 23 (2015), pp. 80-84
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WHO
Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach
Copyright © 2018. Sociedade Brasileira de Infectologia
The Brazilian Journal of Infectious Diseases

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