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Vol. 19. Num. 4.July - August 2015
Pages 339-452
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Vol. 19. Num. 4.July - August 2015
Pages 339-452
Original article
DOI: 10.1016/j.bjid.2015.04.004
Open Access
Disease burden of chronic hepatitis C in Brazil
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Paulo Roberto Abrão Ferreiraa,
Corresponding author
paulo.abrao.ferreira@gmail.com

Corresponding author at: Rua Ouvidor Peleja, 235 ap 101, São Paulo, SP 04128000, Brazil.
, Carlos Eduardo Brandão-Mellob, Chris Estesc, Fernando Lopes Gonçales Júniord, Henrique Sérgio Moraes Coelhoe, Homie Razavic, Hugo Cheinquerf, Fernando Herz Wolfff, Maria Lúcia Gomes Ferrazg, Mário Guimarães Pessoah, Maria Cássia Mendes-Correai
a Division of Infectious Disease, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
b Department of Gastroenterology, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, RJ, Brazil
c Center for Disease Analysis (CDA), Louisville, CO, USA
d Grupo de Estudo das Hepatites, Disciplina de Doenças Infecciosas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), São Paulo, SP, Brazil
e Department of Clinical Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
f Hospital das Clínicas da Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre, RS, Brazil
g Division of Gastroenterology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
h Division of Gastroenterology and Hepatology, Escola de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil
i Escola de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil
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Abstract
Background

Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.

Methods

Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).

Results

The number of infected individuals is estimated to decline by 35% by 2030 (1,255,000 individuals); while the number of cases of compensated (n=325,900) and decompensated (n=45,000) cirrhosis; hepatocellular carcinoma (n=19,100); and liver-related deaths (n=16,700) is supposed to peak between 2028 and 2032. In strategy 2; treated cases increased over tenfold in 2020 (118,800 treated) as compared to 2013 (11,740 treated); with sustained virological response increased to 90% and treatment eligibility to 95%. Under this strategy; the number of infected individuals decreased by 90% between 2013 and 2030. Compared to the base case; liver-related deaths decreased by 70% by 2030; while hepatitis C virus-related liver cancer and decompensated cirrhosis decreased by 75 and 80%; respectively.

Conclusions

While the incidence and prevalence of hepatitis C virus in Brazil are decreasing; cases of advanced liver disease continue to rise. Besides higher sustained virological response rates; new strategies focused on increasing the proportion of diagnosed patients and eligibility to treatment should be adopted in order to reduce the burden of hepatitis C virus infection in Brazil.

Keywords:
HCV
Disease burden
Epidemiology
Incidence
Brazil
Abbreviations:
HCV
Anti-HCV
HCC
IDU
DAA
SVR
Peg-IFN
G1HCV
Full Text
Introduction

Infection with the hepatitis C virus (HCV) is a leading cause of cirrhosis, hepatocellular carcinoma (HCC) and liver transplants in Brazil.1,2 The seroprevalence, measured by detection of anti-HCV in large Brazilian cities, was 1.38%, which represents about two million people infected.3 However, it is estimated that only twenty thousand HCV infected patients are diagnosed annually in Brazil, with as few as ten thousand being selected for treatment each year.4,5

In 2002, the Brazilian Ministry of Health created the Viral Hepatitis National Program with goals for reducing the incidence of viral hepatitis and improving the quality of life for infected individuals.6 Harm reduction measures aimed at reducing transmission among injecting drug users (IDU), along with universal precautions measures for preventing nosocomial transmission, improvement of diagnostic methods, and distribution of medications in all regions of the country were adopted, but were insufficient to decrease hepatitis C prevalence significantly. This observation is related to low rate of inclusion to treatment and a small chance to cure with interferon and ribavirine.4,5 The release of new direct-acting antiviral agents (DAA) with lower adverse event rates, broader eligibility criteria, and higher sustained virological response (SVR) rates have the potential to reduce the prevalence, and thereby reduce transmission and new HCV cases. Besides reducing new cases, SVR can prevent the evolution of already infected patients to cirrhosis, advanced liver disease, and cirrhosis decompensation, improving the quality of life for these individuals.7 However, how much these new treatment options will impact on HCV prevalence and burden in a nationwide perspective is unknown.

The development of statistical modeling allows predicting the long-term influence of detection rates and antiviral treatments on population morbidity and mortality. These models must be established with the relevant information to each country in order to provide forecasts that enable interventions in public health.8

The objectives of this study were to describe the key data to build a statistical model for hepatitis C epidemiology in Brazil, to analyze the current and future importance of chronic HCV infection in the Brazilian population, and to simulate the impact of two possible future strategies to control hepatitis C in Brazil.

Methods

Key parameters were gathered through a literature search: country population, seroprevalence, viremic infection prevalence, genotype distribution, total and annual cases diagnosed, annual number of patients treated, and total HCV liver transplants. When data were not available, expert consensus or expert opinions were used to create base case estimates.

Model

A modeling approach to describe the burden of chronic HCV infection in Brazil was used based in a previously described model.9 Briefly, a disease progression model was constructed in Microsoft Excel (Microsoft Corp., Redmond, WA) to quantify the size of the HCV-infected population by liver disease stages, from 1950 to 2030. Frontline Systems’ Solver, was used to calculate the number, age and gender distribution of annual acute infections. The model started with the annual number of acute infections that progressed to chronic HCV infection after accounting for spontaneous clearance of the virus. The progression of these new cases was followed along with all chronic infections from prior years.

Then two strategies for addressing chronic HCV infection in Brazil and their effect on HCV-related morbidity and mortality were considered. In strategy 1, SVR rate increases in 2014 to 80% for genotypes 1, 2 and 4, and to 70% for genotype 3. Eligibility to treatment increases to 85% in individuals infected with genotypes 2 or 3. In 2016, medical eligibility was increased to 85% for all genotypes, and SVR to 85% for genotypes 1, 3 and 4, and 90% for genotype 2. In 2018, medical eligibility and SVR rates were increased to 95% for all genotypes.

In strategy 2, the same treatment eligibility and SVR rates as strategy 1 were used. However, the annual number of diagnosed patients increases, in 2014, to 30,000 as compared to 10,000 in 2013, and the number of treated patients increases to 15,260 in 2014, as compared to 11,740 in 2013. In 2016, the annual number of newly diagnosed patients increased to 90,000, and the annual number of treated patients to 30,520. In addition, this model considers treating patients with any HCV genotype with a Metavir fibrosis score ≥F2. In 2018, the annual diagnosed population was set at 270,000, and annual treated population was set at 91,570. At this point all patients with a Metavir fibrosis score ≥F1 would be treated. In 2020, the parameters includes a total of 109,880 patients up to age 74 and any fibrosis stage (Metavir ≥F0) been treated annually.

Total population

Brazilian population data were organized by gender and five-year age cohorts according to United Nations population database.10

Total Infected

Total HCV seroprevalence was estimated from a national study at 1.38% in 2007, the midpoint of the data collection period (2005–2009).3 Age and gender specific HCV incidence by five-year age group reported by the Brazilian Ministry of Health was used to calculate age and gender specific prevalence rates.4 HCV genotype distribution was based upon a study of blood samples collected between 1995 and 2000 from all Brazilian states. This study found a distribution of 64.9, 4.6, 30.2, and 0.3% for genotypes 1, 2, 3 and 4, respectively.11 (Fig. 1)

Fig. 1.
(0.1MB).

Anti-HCV prevalence according to age and gender, Brazil, 2007.

Transition probabilities

Age and gender specific disease progression probabilities were simulated by multiplying the total number of cases at a particular stage of the disease by a progression rate to the next stage. A more detailed description is provided in a previously published paper.9

New cases

To estimate changes in annual incidence over time, we used estimates based on United States data.12 The magnitude of incidence, when not available for a specific year, gender or age group, was back-calculated based on the prevalence in 2007.3

Treated patients

In 2010, it is estimated that 11,750 patients were treated in Brazil. We used IMS Health data for standard units of peguilated interferon (Peg-IFN) sold in Brazil, with a multiplier to account for under-reporting.5 The Brazilian genotype distribution was used to estimate the average number of weeks of treatment per patient. After accounting for underreporting, we estimate that in 2010, over 372,000 units of Peg-IFN sold in Brazil. With 85% compliance/persistence, we estimate an average of 31.7 units and 39.6 weeks per patient.

Liver transplants

In 2011, there were 1494 liver transplants in Brazil. Based on expert consensus, it is estimated that 50% of transplants were related to HCV in 1997, declining to 30% by 2011. This was validated using a regional estimate for the proportion of transplants related to HCV.2

Diagnosed patients

Based on expert consensus, the number of people living with a diagnosis of HCV chronic infection in 2013 in Brazil was estimated to be 300,000. Each year, it was estimated that 10,000 viremic individuals are newly diagnosed.

Mortality and risk factors

Background mortality rates by age group and gender were calculated using United Nations mortality data.13 To account for excess mortality in the IDU population, we estimated that 5.1% of the prevalent population are active IDU, based on data from a national study.3 Increased mortality among active IDU was estimated using standardized mortality ratio of 10.0 for individuals between 15 and 44 years of age.14–19 In addition, we considered excess mortality among blood transfusion recipients. In Brazil, a national study estimated that 14.8% of the HCV population was infected through blood transfusion.3 For this population, a standardized mortality ratio of 1.5 was applied for all age groups.20

ResultsBase case

For the base case, the current Brazilian Ministry of Health recommendation for HCV treatment was considered. Thus, patients between 18 and 69 years of age have been treated. For HCV genotype 1 (G1) infected individuals, treatment with protease inhibitors (telaprevir or boceprevir) is supposed to be prescribed for individuals with Metavir fibrosis score ≥F3. Individuals with G1 and lower fibrosis (Metavir21 while an SVR of 70% was assumed for HCV genotypes 2 and 3 treated patients.22

Based on these inputs, the prevalence of HCV viremic individuals peaked in 1996 at 2,255,000, and a total of 1,938,700 were viremic in 2013. By 2030, it was estimated that will be over 1,255,000 viremic HCV infected individuals in Brazil, and over 16,600 HCV-related annual liver deaths. We estimate 45,000 cases of decompensated cirrhosis and 18,900 HCC cases by 2030. Approximately 35% of the infected population will be cirrhotic or have advanced liver disease (Fig. 2).

Fig. 2.

Base case model outputs. (A) Total viremic cases, by age, 2013; (B) Annual mortality due to liver related and background cause, 2013–2030; (C) Number of viremic cases, in total, and by disease stage, 1950–2030; (D) Expanded graph of viremic cases by disease stage for cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma, 1950–2030.

Strategy 1: increase SVR

As a result of strategy 1 (increase in SVR only), the total number of infected individuals would decline by 46,000 in 2030 as compared to the base case, a 3.7% reduction. In addition, cumulative HCV-related mortality would decrease by 7570 deaths (2.5%) during 2013–2030 as compared to the base case. Cases of HCV-related HCC and decompensated cirrhosis would decrease by 2290 cases (5.1%) and 6030 cases (3.2%) in 2030, respectively, as compared to the base case.

Strategy 2: HCV elimination as a result of this strategy (increase in SVR associated with an increase in HCV diagnosed and treated individuals), the HCV infected population declines to 190,600 individuals by 2030, an 85% decrease as compared to the base case. Prevalent cases of decompensated cirrhosis and liver cancer in 2030 decrease, respectively, by 36,350 (81% decrease), and 13,810 (73% decrease) cases as compared to the base case. Finally, cumulative HCV-related mortality from 2013 to 2030 declines by 84,880 deaths, a 28% reduction as compared to the base case (Figs. 3 and 4).

Fig. 3.
(0.12MB).

Background and liver related mortality projections under the base case and three strategies, 2013–2030.

Fig. 4.
(0.32MB).

Total viremic cases and viremic cases by disease stage. Projections under the base case (A), and strategies 1 (B) and 2 (C) with estimates for cirrhosis, decompensated cirrhosis and HCC, 1950–2030.

Discussion

About 11,200 new HCV infections diagnosis occurred in Brazil in 2013. The viremic prevalence is estimated to have peaked in 1996 (2,255,000 individuals) and expected to decline by 45% in 2030 (1,255,000 individuals). However, the number of cases of compensated (325,900) and decompensated (45,000) cirrhosis, HCC (19,100), and liver-related deaths (16,700) will peak between 2028 and 2032. These projections can be worse if influenced by external factors, like public health system quality.

Implementation of Strategy 1 resulted in a slow decrease in HCV-related morbidity and mortality in the future, without increasing the size of the diagnosed or treated population. However, the impact of Strategy 2 was much larger, showing that substantial increase in the annual treated and diagnosed populations is necessary to achieve elimination of chronic hepatitis C (<150,000 viremic cases). In strategy 2 simulation, the model considered an increase in treated cases over tenfold in 2020 (118,800) as compared to 2013 (11,740), an SVR increase to 90% and treatment eligibility to 95% (among 15–74 years with a fibrosis Metavir score ≥F1). Compared to the base case, this strategy decreased prevalent infections and decreased liver-related deaths. HCV-related liver cancer and decompensated cirrhosis also decreased.

It is noteworthy that the time between the peak prevalence of hepatitis C and the peak incidence of liver complications and HCC is more than 30 years. Consequently, the number of elderly patients affected by this complication will be high. This fact can bring greater complexity to the clinical care of these patients and a worse prognosis.11

To avoid the consequences of hepatitis C burden along time, Brazil needs a public health program with planned, consistent and continued upgrade actions in next decades. It is necessary to increase the number of centers to take care of these patients, assign specifics tasks to primary, secondary and tertiary levels of health care, and a network with geographical distribution (reference/counter-reference system). The three levels of government (federal, provincial and municipal) must coordinate actions to increase identification and access of infected patients to treatment and care. The health care workers must be trained in a multiprofessional approach.

The limitations of this study are mainly related to the unavailability of Brazilian data and the assumptions already presented. Some data from other countries were used for completion of the model. For example, the relative reduction in observed incidence was based on United States data.11 To minimize this weakness, once we have gathered all the available published data, a group of Brazilian experts was consulted for validation.

In conclusion, the above mentioned projections, show how important is to identify infected patients and begin treatment with more tolerable and effective medications to all patients, especially those with less advanced fibrosis (Metavir

Conflicts of interest

The authors declare no conflicts of interest.

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The Brazilian Journal of Infectious Diseases

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