Adult urologyHuman papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection
Section snippets
Material and methods
The present cross-sectional study evaluated 50 heterosexual male, stable sexual partners of confirmed HPV-infected women seen at the outpatient unit of pathology of the lower genital tract at the university hospital using the Hybrid Capture 2 (hc2; Digene). The study was conducted between September 1997 and May 2000. All patients provided written informed consent, and the institutional review board approved the study. A stable relationship was defined as a duration of longer than 6 months,
Results
The mean age of the 50 men was 31 years (range 19 to 53 years). On average, the current sexual relationship lasted for 71 months (range 6 to 360 months). The mean age at first sexual intercourse was 14.9 years (range 12 to 19 years). On average, couples reported sexual intercourse three times per week (range one to seven). A previous episode of a sexually transmitted disease was reported by 11 (22.4%) of 49 men and regular condom use by 9 (18.4%) of 49. Of the 50 men, 20 (40%) reported sexual
Comment
The results of this study have demonstrated that the best strategy to diagnose HPV infection in men is HPV DNA testing. In that regard, HPV DNA positivity in brushed material was greater than in biopsy fragments of the same affected area. Although the prepuce internal surface was the penile area where HPV DNA was most frequently detected, collecting from the urethra contributed significantly to HPV detection. The HPV group (high-risk or low-risk) of the female partner did not predict the male
Conclusions
Although examination of the male partners of women with identified HPV infections is of unclear value, our data underscored the role of HPV DNA tests. Brushed material collected from the distal urethra, in addition to the external surface of the penis, seems to be the optimal approach for diagnosing HPV infection in men.
Acknowledgment
To Cristiane Gallo and Eliane Taromaru who worked at Digene of Brazil at the time of the study and processed all the Hybrid Capture tests.
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2014, Journal of Infection and ChemotherapyCitation Excerpt :Giuliano et al. examined the presence of HPV-DNA in multiple genital sites of 463 healthy men and reported that HPV was most commonly detected on the penile shaft (49.9%), followed by the glans (35.8%), scrotum (34.2%), perianal area (20.0%), anal canal (17.6%), urethra (10.1%), and semen (5.3%); the HPV detection rate was the poorest in urine samples (0.8%) [9]. Furthermore, Nicolau et al. determined the prevalence of HPV-DNA according to some anatomical sites in 50 male partners of HPV-infected women and found that HPV detection was 44% in the inner prepuce, 30% in the distal urethra, 24% in the glans, 24% in the external prepuce of penile shaft, 12% in the scrotum, and 8% in the anus [10]. However, many previous studies have failed to detect HPV infection in the urinary tract, especially from urine samples.
This study was partially supported by the Digene Corporation-USA.
G. B. das Dores and A. Lorincz hold stock in the sponsor.