Editorial
Explaining the unexplained hepatitis in children

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Cited by (19)

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    2023, Artificial Intelligence, Machine Learning, and Deep Learning in Precision Medicine in Liver Diseases: Concept, Technology, Application and Perspectives
  • Water, sanitation and hygiene (WASH) in schools in Brazil pre-and peri-COVID-19 pandemic: Are schools making any progress?

    2023, International Journal of Hygiene and Environmental Health
    Citation Excerpt :

    However, the transmission of the new coronavirus among children is of special concern taking into account the associated increased incidence of Kawasaki disease and Multisystem inflammatory syndrome cases in children (MIS-C) (Dufort et al., 2020; Godfred-cato et al., 2020; Okarska-Napierała et al., 2020; Verdoni et al., 2020) and the emergence of the new pediatric hepatitis with unknown cause (Brodin and Arditi, 2022; Kendall et al., 2022. ; The Lancet Infectious Diseases, 2022). Moreover, children can also experience the manifestation of persistent long-term COVID-19 symptoms after the infection (long COVID), which can ultimately result in their cognitive development impairment (Asadi-Pooya et al., 2021; Borch et al., 2022).

  • Hepatitis of unknown etiology in children in Brazil: A new challenge or the usual scenario ?

    2022, Brazilian Journal of Infectious Diseases
    Citation Excerpt :

    In our analysis, the incidence rate of hospital admissions per 1000 all-cause hospitalizations, the proportion of liver transplantations and deaths during a hospital stay due to hepatitis with unknown etiology in children/adolescents were similar in the pre-pandemic (2019) period and during subsequent years of the COVID-19 pandemic (Jan 2020-Feb 2022). Several hypotheses have been raised to explain the causes of those non-A-E hepatitis cases.12 Adenoviruses infections have become one of the most suspected etiologic agents since up to 53% of cases in Europe tested positive.4

  • Acute hepatitis of unknown origin in Europe—Adding fuel to already burning pandemic

    2022, Annals of Medicine and Surgery
    Citation Excerpt :

    The aetiology of this severe acute hepatitis is unknown; the cases are clinically more severe, and a higher proportion develops acute liver failure, as compared to earlier reports of acute hepatitis in children with an unknown aetiology [1]. Adenoviruses have become the focus of investigations after a large number of cases were found to be infected with them [3]. The majority of cases were observed to present with gastrointestinal symptoms such as stomach discomfort, diarrhea, and vomiting, followed by the appearance of jaundice [4].

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