TY - JOUR T1 - Clinical and epidemiological aspects of Candidemia in eight medical centers in the state of Parana, Brazil: Parana Candidemia Network JO - The Brazilian Journal of Infectious Diseases T2 - AU - de Oliveira,Carla Sakuma AU - Colombo,Arnaldo Lopes AU - Francisco,Elaine Cristina AU - de Lima,Bernardo AU - Gandra,Rinaldo F. AU - de Carvalho,Mariza Cristina Preifz AU - Carrilho,Cláudia Maria Dantas de Maia AU - Petinelli,Renan AU - Pelison,Marsilene AU - Helbel,Cesar AU - Czelusniak,Gerson AU - Paz Morales,Hugo Manuel AU - Perozin,Jamile Sardi AU - Pinheiro,Rosangela Lameira AU - Cognialli,Regielly AU - Breda,Giovanni Luis AU - Queiroz-Telles,Flávio SN - 14138670 M3 - 10.1016/j.bjid.2020.11.006 DO - 10.1016/j.bjid.2020.11.006 UR - https://bjid.org.br/en-clinical-epidemiological-aspects-candidemia-in-articulo-S1413867020301689 AB - ObjectivesCandida spp. has been reported as one of the common agents of nosocomial bloodstream infections and is associated with a high mortality. Therefore, this study evaluated the clinical findings, local epidemiology, and microbiological aspects of candidemia in eight tertiary medical centers in the state of Parana, South of Brazil. MethodsIn this study, we reported 100 episodes of candidemia in patients admitted to eight different hospitals in five cities of the state of Parana, Brazil, using data collected locally (2016 and 2017) and tabulated online. ResultsThe incidence was found to be 2.7 / 1000 patients / day and 1.2 / 1000 admissions. C. albicans was responsible for 49% of all candidemia episodes. Cancer and surgery were the two most common underlying conditions associated with candidemia. The mortality rate within 30 days was 48%, and removal of the central venous catheter (p = 0.029) as well as empirical or prophylactic exposure to antifungals were both related to improved survival (p = 0.033). ConclusionsThis study highlights the high burden and mortality rates of candidemia in hospitals from Parana as well as the need to enhance antifungal stewardship program in the enrolled medical centers. ER -