TY - JOUR T1 - Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales JO - The Brazilian Journal of Infectious Diseases T2 - AU - Reyes,Jorge Aníbal AU - Melano,Roberto AU - Cárdenas,Paúl Andrés AU - Trueba,Gabriel SN - 14138670 M3 - 10.1016/j.bjid.2020.03.002 DO - 10.1016/j.bjid.2020.03.002 UR - https://bjid.org.br/en-mobile-genetic-elements-associated-with-articulo-S1413867020300234 AB - IntroductionCarbapenem resistance in members of order Enterobacterales is a growing public health problem causing high mortality in developing and industrialized countries. Its emergence and rapid propagation worldwide was due to both intercontinental spread of pandemic strains and horizontal dissemination via mobile genetic elements (MGE) such as plasmids and transposons. ObjectiveTo describe MGE carrying carbapenem resistance genes in Enterobacterales which have been reported in South America. Search strategy and selection criteriaA search of the literature in English or Spanish published until 2019 in PubMed, Google Scholar, LILACS and SciELO databases was performed for studies of MGE in Enterobacterales reported in South American countries. ResultsSeven South American countries reported MGE related to carbapenemases. Carbapenemase-producing Klebsiella pneumoniae belonging to clonal complex 258 were the most prevalent pathogens reported; others carbapenemase-producing Enterobacterales such as Escherichia coli, Serratia marcescens, and Providencia rettgeri also have been reported. The MGE implicated in the spread of the most prevalent carbapenemase genes are Tn4401 and non-Tn4401 elements for blaKPC and ISAba125 for blaNDM, located in different plasmid incompatibility groups, i.e. L/M, A/C, FII and bacterial clones. ConclusionThis review indicates that, like in other parts of the world, the most commonly reported carbapenemases in Enterobacterales from South America are being disseminated through clones, plasmids, and transposons which have been previously reported in other parts of the world. ER -