TY - JOUR T1 - Non-polarized cytokine profile of a long-term non-progressor HIV infected patient JO - The Brazilian Journal of Infectious Diseases T2 - AU - Pina,Ana Flávia AU - Matos,Vanessa Terezinha Gubert de AU - Bonin,Camila Mareti AU - Dal Fabbro,Márcia Maria Ferrairo Janini AU - Tozetti,Inês Aparecida SN - 14138670 M3 - 10.1016/j.bjid.2018.01.003 DO - 10.1016/j.bjid.2018.01.003 UR - https://bjid.org.br/en-non-polarized-cytokine-profile-long-term-non-progressor-articulo-S1413867017307146 AB - The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles. ER -