TY - JOUR T1 - Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis JO - The Brazilian Journal of Infectious Diseases T2 - AU - Cordeiro,Cynthia Azeredo AU - Vieira,Erica Leandro Marciano AU - Rocha,Natália Pessoa AU - Castro,Vinicius Monteiro AU - Oréfice,Juliana Lambert AU - Barichello,Tatiana AU - Costa,Rogerio Alves AU - Oréfice,Fernando AU - Young,Lucy AU - Teixeira,Antonio Lucio SN - 14138670 M3 - 10.1016/j.bjid.2016.11.005 DO - 10.1016/j.bjid.2016.11.005 UR - https://bjid.org.br/en-serum-levels-neurotrophic-factors-in-articulo-S1413867016305840 AB - Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. MethodsTwenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. ResultsBDNF levels were significantly higher in patients before treatment when compared with controls (p=0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. ConclusionBDNF may be released in the context of the active TR inflammatory response. ER -