TY - JOUR
T1 - Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress
JO - The Brazilian Journal of Infectious Diseases
T2 -
AU - Mukherjee,Debarati
AU - Singh,Chingakham Brajakishor
AU - Dey,Somaditya
AU - Mandal,Supratim
AU - Ghosh,Joydip
AU - Mallick,Suvadip
AU - Hussain,Aabid
AU - Swapana,Ningombam
AU - Ross,Samir Anis
AU - Pal,Chiranjib
SN - 14138670
M3 - 10.1016/j.bjid.2015.10.002
DO - 10.1016/j.bjid.2015.10.002
UR - https://bjid.org.br/en-induction-apoptosis-by-zerumbone-isolated-articulo-S1413867015002032
AB - In the present context of emergence of resistance aligned with the conventional anti-leishmanial drugs and occasional treatment failure compelled us to continue the search for replaceable therapeutic leads against Leishmania infection. Various ginger spices of the Zingiberaceae family are widely used as spices, flavouring agents, and medicines in Southeast Asia because of their unique flavour as well as due to their medicinal properties. Zerumbone, a natural component of Zingiber zerumbet (L.) Smith, has been studied for its pharmacological potential as antiulcer, antioxidant, anticancer, and antimicrobial. In this study, we have shown that zerumbone could induce ROS mediated apoptosis in Leishmania donovani promastigotes and also found effective in reducing intracellular amastigotes in infected-macrophages. We emphasized the potential of zerumbone to be employed in the development of new therapeutic drugs against L. donovani infection and provided the basis for future research on the application of transitional medicinal plants.
ER -