The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:176-9 - Vol. 21 Num.2 DOI: 10.1016/j.bjid.2016.11.005
Brief communication
Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis
Cynthia Azeredo Cordeiroa,b,c, Erica Leandro Marciano Vieiraa, Natália Pessoa Rochaa, Vinicius Monteiro Castroa,b, Juliana Lambert Oréficeb, Tatiana Barichellod,e, Rogerio Alves Costab, Fernando Oréficeb, Lucy Youngc, Antonio Lucio Teixeiraa,e,,
a Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil
b Centro Brasileiro de Ciências Visuais, Belo Horizonte, MG, Brazil
c Massachusetts Eye and Ear Infirmary, Retina Department, Boston, United States
d Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil
e The University of Texas Health Science Center at Houston, McGovern Medical School, Department of Psychiatry and Behavioral Sciences, Houston, United States
Received 11 April 2016, Accepted 16 November 2016
Abstract

Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.

Methods

Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.

Results

BDNF levels were significantly higher in patients before treatment when compared with controls (p=0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.

Conclusion

BDNF may be released in the context of the active TR inflammatory response.

Keywords
Retinochoroiditis, Toxoplasma gondii, Brain-derived neurotrophic factor
Braz J Infect Dis 2017;21:176-9 - Vol. 21 Num.2 DOI: 10.1016/j.bjid.2016.11.005