The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:535-9 - Vol. 21 Num.5 DOI: 10.1016/j.bjid.2017.05.004
Original article
High prevalence of hepatitis E virus antibodies in Sao Paulo, Southeastern Brazil: analysis of a group of blood donors representative of the general population
Ana Maria Passos-Castilhoa,,, , Mônica Renata Reinaldoa,, Anne de Senaa,b, Celso F.H. Granatoa,b
a Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
b Fleury SA Group, Sao Paulo, SP, Brazil
Received 24 February 2017, Accepted 11 May 2017
Abstract

Brazil is a non-endemic country for hepatitis E virus (HEV) infection with seroprevalence from 1% to 4% in blood donors and the general population. However, data on seroprevalence of HEV in the country are still limited. This study evaluated the prevalence of past or present HEV infection in a group of blood donors representative of the general population of the city of Sao Paulo, Southeastern Brazil. Serum samples from 500 blood donors were tested from July to September 2014 by serological and molecular methods. Anti-HEV IgG antibodies were detected in 49 (9.8%) subjects and categorized age groups revealed an age-dependent increase of HEV seroprevalence. Among the anti-HEV IgG positive subjects, only 1 had anti-HEV IgM while none tested positive for HEV-RNA. The present data demonstrate a higher seroprevalence of anti-HEV IgG than previously reported in the region.

Keywords
Hepatitis E virus, Blood donors, Seroprevalence, Brazil
Braz J Infect Dis 2017;21:535-9 - Vol. 21 Num.5 DOI: 10.1016/j.bjid.2017.05.004