The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:577-80 - Vol. 21 Num.6 DOI: 10.1016/j.bjid.2017.06.007
Original article
Comparison of the ACC/AHA and Framingham algorithms to assess cardiovascular risk in HIV-infected patients
Lauro Ferreira da Silva Pinto Netoa,, , Fernanda Rezende Diasb, Flavia Feres Bressanb, Carolina Rocio Oliveira Santosa
a Escola de Ciências da Santa Casa de Vitória, Unidade de Doenças Infecciosas, Vitória, ES, Brazil
b Santa Casa de Misericórdia de Vitória, Vitória, ES, Brazil
Received 06 November 2016, Accepted 20 June 2017
Abstract

The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. 61.3% were stratified as low risk by Framingham score, compared with 54% by ACC/AHA score (Spearman correlation 0.845; p<0.000). Only 26.1% were classified as cardiovascular high risk by Framingham compared to 46% by ACC/AHA score (Kappa=0.745; p<0.039). Only one out of eight patients had cardiovascular high risk by Framingham at the time of a myocardial infarction event registered up to five years before the study period. Both cardiovascular risk scores but especially Framingham underestimated high-risk patients in this HIV-infected population.

Keywords
Cardiovascular disease, HIV, Co-morbidities, Non-AIDS events
Braz J Infect Dis 2017;21:577-80 - Vol. 21 Num.6 DOI: 10.1016/j.bjid.2017.06.007