The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:468-71 - Vol. 21 Num.4 DOI: 10.1016/j.bjid.2017.04.003
Brief communication
A prospective observational cohort study to assess the incidence of acute otitis media among children 0–5 years of age in Southern Brazil
Tatiana M. Lanzieria,, , Clóvis Arns da Cunhab, Rejane B. Cunhac, D. Fermin Arguellod, Raghavendra Devadigae, Nervo Sancheza, Eduardo Ortega Barriad
a GSK, Rio de Janeiro, RJ, Brazil
b Universidade Federal do Paraná, Hospital de Clínicas, Divisão de Doenças Infecciosas, Curitiba, PR, Brazil
c Hospital Nossa Senhora das Graças, Departamento de Pediatria, Curitiba, PR, Brazil
d GSK, Panama City, Panama
e GSK Pharmaceuticals Limited, Bangalore, Karnataka, India
Received 18 October 2016, Accepted 19 April 2017
Abstract
Objectives

To estimate acute otitis media incidence among young children and impact on quality of life of parents/caregivers in a southern Brazilian city.

Methods

Prospective cohort study including children 0–5 years of age registered at a private pediatric practice. Acute otitis media episodes diagnosed by a pediatrician and impact on quality of life of parents/caregivers were assessed during a 12-month follow-up.

Results

During September 2008–March 2010, of 1,136 children enrolled in the study, 1074 (95%) were followed: 55.0% were ≤2 years of age, 52.3% males, 94.7% white, and 69.2% had previously received pneumococcal vaccine in private clinics. Acute otitis media incidence per 1000 person-years was 95.7 (95% confidence interval: 77.2–117.4) overall, 105.5 (95% confidence interval: 78.3–139.0) in children ≤2 years of age and 63.6 (95% confidence interval: 43.2–90.3) in children 3–5 years of age. Acute otitis media incidence per 1000 person-years was 86.3 (95% confidence interval: 65.5–111.5) and 117.1 (95% confidence interval: 80.1–165.3) among vaccinated and unvaccinated children, respectively. Nearly 68.9% of parents reported worsening of their overall quality of life.

Conclusion

Acute otitis media incidence among unvaccinated children in our study may be useful as baseline data to assess impact of pneumococcal vaccine introduction in the Brazilian National Immunization Program in April 2010.

Keywords
Acute otitis media, Children, Incidence, Quality of life
Braz J Infect Dis 2017;21:468-71 - Vol. 21 Num.4 DOI: 10.1016/j.bjid.2017.04.003