The Brazilian Journal of Infectious Diseases The Brazilian Journal of Infectious Diseases
Braz J Infect Dis 2017;21:587-95 - Vol. 21 Num.6 DOI: 10.1016/j.bjid.2017.06.005
Original article
A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1–24 years in the city of Embu das Artes, São Paulo, Brazil
Lily Yin Weckxa,, , Rosana Fiorini Puccinia, Antónia Machadob, Maria Gisele Gonçalvesc, Suely Tuboid, Eliana de Barrosd, Raghavendra Devadigae, Eduardo Ortega-Barriaf, Romulo Colindresd
a Universidade Federal de São Paulo, Departamento de Pediatria, São Paulo, SP, Brazil
b Universidade Federal de São Paulo, Departamento de Medicina, São Paulo, SP, Brazil
c Instituto Adolfo Lutz, Instituto de Imunologia, São Paulo, SP, Brazil
d GSK Brazil, Rio de Janeiro, RJ, Brazil
e GSK, Bangalore, India
f GSK, Ciudad de Panama, Panama
Received 14 December 2016, Accepted 20 June 2017
Abstract

Meningococcal carriage is a prerequisite for invasive infection. This cross-sectional study assessed the pharyngeal carriage prevalence in healthy subjects aged 1–24 years in Embu das Artes city, São Paulo, Brazil. Pharyngeal swabs were examined for the presence of Neisseria meningitidis. The isolates were tested for different serogroups using agglutination and polymerase chain reaction. A logistic regression model assessed any independent association between Neisseria meningitidis carriage and various risk factors. A total of 87/967 subjects (9%, 95% Confidence Interval (CI): 7.3–11.0) tested positive for N. meningitidis: 6.2% (95% CI: 3.8–9.4) in 1–4 years, 8.5% (95% CI: 5.1–13.0) in 5–9 years, 12.5% (95% CI: 7.8–18.6) in 10–14 years, 12.6% (95% CI: 7.4–19.7) in 15–19 years and 9% (95% CI: 4.9–14.9) in 20–24 years age groups. Highest carriage prevalence was observed in adolescents 10–19 years old. Serogroup C was predominant (18.4%) followed by serogroup B (12.6%). The 15–19 years age group showed a significant association between number of household members and carriers of N. meningitidis. This cross-sectional study is the first in Brazil to evaluate meningococcal carriage prevalence and associated factors in a wide age range.

Keywords
Carriage, Meningococcal disease, Neisseria meningitidis, Pharyngeal, Serogroup
Braz J Infect Dis 2017;21:587-95 - Vol. 21 Num.6 DOI: 10.1016/j.bjid.2017.06.005