TY - JOUR T1 - Emerging carbapenem-resistant Aeromonas spp. infections in Cali, Colombia JO - The Brazilian Journal of Infectious Diseases T2 - AU - Rosso,Fernando AU - Cedano,Jorge Andrés AU - Parra-Lara,Luis Gabriel AU - Sanz,Ana María AU - Toala,Alejandra AU - Velez,Jolian Fernando AU - Hormaza,María Paula AU - Moncada,Pablo Andrés AU - Correa,Adriana SN - 14138670 M3 - 10.1016/j.bjid.2019.08.005 DO - 10.1016/j.bjid.2019.08.005 UR - https://bjid.org.br/en-emerging-carbapenem-resistant-aeromonas-spp-infections-articulo-S1413867019304234 AB - IntroductionAeromonas species are renowned enteric pathogens with virulence determinants linked to human diseases, such as gastroenteritis, skin, soft-tissue and muscle infections, and septicemia. A recent concern of resistance in this organism has emerged, especially the presence carbapenemases. Herein we describe a case series of emerging carbapenem-resistant Aeromonas species infection in our hospital in Cali, Colombia. Materials and methodsCases from 2012 to 2018 are reported. Clinical data was abstracted from the clinical charts and laboratory information. Phenotypic detection of resistance was identified using the VITEK®2 system (BioMérieux) and broth microdilution MicroScan WalkAway plus System (Beckman Coulter). CARBA NP-test and multiplex qPCR assay was performed in 11 isolates to identify genes encoding carbapenemases (blaKPC, blaVIM, blaIMP and blaNDM). Results21 cases of Aeromonas infection in hospitalized patients with phenotypic resistance to carbapenems were studied. The median age was 50 years, 55% (12/21) were male, and 67% (14/21) were healthcare-associated infections (HAI). Aeromonas hydrophila was the most common species (19/21). Forty-three percent (9/21) of the patients were immunocompromised. The mortality was 33% (7/21), and in patients with bacteremia was 100%. Most patients received empirical treatment with meropenem and failed to this treatment. PCR amplification tests showed negative results for the carbapenemases analyzed. ConclusionEmerging phenotypic carbapenem-resistant infection has been seen in our hospital, most as HAI. High mortality was found, especially in immunocompromised patients and in those who failled empirical treatment with carbapenems. As the main carbapenemases tested were negative, carbapenem-resistant could be attributed to an intrinsic metallo-β-lactamase, CphA encoded by the cphA gene, possible hyperproduction of ampC β-lactamase and/or porins expression. ER -