TY - JOUR T1 - Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome JO - The Brazilian Journal of Infectious Diseases T2 - AU - Rodrigues,Maria de Lourdes AU - Deghaide,Neifi Hassam AU - Figueiredo,JosĂ© Fernando AU - de Menezes,Marcelo Bezerra AU - Demarco,Ana LĂșcia AU - Donadi,Eduardo AU - Fernandes,Ana Paula SN - 14138670 M3 - 10.1016/j.bjid.2015.10.010 DO - 10.1016/j.bjid.2015.10.010 UR - https://bjid.org.br/en-toxoplasmic-encephalitis-role-human-leucocyte-articulo-S1413867015002226 AB - Background/aimsThe frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndrome with and without Toxoplasmic Encephalitis. Methods114 patients with Acquired Immunodeficiency Syndrome (41 with Toxoplasmic Encephalitis, 43 with anti-Toxoplasma gondii antibodies, without Toxoplasmic Eencephalitis, and 30 without anti-Toxoplasma gondii antibodies circulating and without Toxoplasmic Encephalitis) were studied. ResultsHuman Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome, particularly HLA-B35, -DR3, and -DR1 allele group, were significantly less represented in patients with Toxoplasmic Encephalitis and Acquired Immunodeficiency Syndrome. ConclusionThe presence of these Human Leucocyte Antigens/Alleles that predispose to Acquired Immunodeficiency Syndrome progression was associated with resistance to Toxoplasmic Encephalitis among Human Immunodeficiency Virus-1 carriers. ER -