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Vol. 15. Issue 5.
Pages 484-485 (September - October 2011)
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Vol. 15. Issue 5.
Pages 484-485 (September - October 2011)
Case report
Open Access
Cutaneous cytomegalovirus infection in a child with hyper IgE and specific defects in antibody response to protein vaccines
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Shahrzad Fallah1, Ahmad Tabatabaei1, Zahra Pournasir2, Zahra Chavoshzadeh3,
Corresponding author
zahra_chavoshzadeh@yahoo.com

Correspondence to: Pediatric Infections Research Center Mofid Children Hospital Shaheed Beheshti Medical University 14194, Tehran, Iran.
, Nima Rezaei4
1 Department of Pediatrics, Mofid Children Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
2 Loghman Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
3 Pediatric Infectious Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
4 Research Center for Immunodeficiencies, Children's Medical Center, and Molecular Immunology Research Center; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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Abstract

Cytomegalovirus (CMV) infection is a common opportunistic systemic infection in immunocompromised patients, but skin involvement is rare. Herein, we report a 10 year-old girl from consanguineous parents who was referred to our center because of disseminated maculopapular rash. She had history of upper and lower respiratory tract infections. In immunological studies, increased serum IgE level and decreased responses to tetanus and diphtheria were detected. Polymerase chain reaction (PCR) examination of bronchoalveolar lavage and serum sample revealed the presence of CMV. Early diagnosis of cutaneous CMV and appropriate treatment are the key actions in management of patients with underlying immunodeficiencies to avoid further complications.

Keywords:
cytomegalovirus infections
antibody formation
common variable immunodeficiency
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References
[1.]
F. Drago, M.G. Aragone, C. Lugani, et al.
Cytomegalovirus infection in normal and immunocompromised humans. A review.
Dermatology, 200 (2000), pp. 189-195
[2.]
A.S. Colsky, S.M. Jegasothy, C. Leonardi, et al.
Diagnosis and treatment of a case of cutaneous cytomegalovirus infection with a dramatic clinical presentation.
J Am Acad Dermatol, 38 (1998), pp. 349-351
[3.]
N. Rezaei, A. Aghamohammadi.
Hyper-IgE syndrome.
J Postgrad Med, 56 (2010), pp. 63-64
[4.]
K.R. Engelhardt, S. McGhee, S. Winkler, et al.
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome.
J Allergy Clin Immunol, 124 (2009), pp. 1289-1302
Copyright © 2011. Elsevier Editora Ltda.. All rights reserved
The Brazilian Journal of Infectious Diseases
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